Liver immunology principles and practice

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Intro -- Preface -- Contents -- Contributors -- 1: Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver -- Danger Signal Recognition by Innate Immune Cells -- Adaptive Immunity -- Antigen Recognition by T-Cell Receptors -- T-Cell...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser:
Gershwin, M. Eric (HerausgeberIn), M. Vierling, John (HerausgeberIn), Tanaka, Atsushi (HerausgeberIn), P. Manns, Michael (HerausgeberIn)
Format:
Elektronisch E-Book
Sprache:
Englisch
Veröffentlicht:
Cham Springer 2020
Ausgabe:
Third edition
Zusammenfassung:
Intro -- Preface -- Contents -- Contributors -- 1: Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver -- Danger Signal Recognition by Innate Immune Cells -- Adaptive Immunity -- Antigen Recognition by T-Cell Receptors -- T-Cell Activation -- Effector Functions of the Adaptive Immune System and Their Regulation -- B-Cell Antigen Receptors (Antibodies) -- Local and Systemic Inflammation -- Regulation of Inflammation -- Liver Anatomy and Microanatomy -- Liver Immune Tolerance -- The Unique Characteristics of Hepatic Immune Cells and Their Role in Supporting Immune Tolerance -- The Influence of Hepatic Exposure to Gut-Derived Products on Liver Tolerance -- The Definition of Autoimmunity and Loss of Immune Tolerance -- Autoimmunity in a Tolerogenic Organ, the Liver -- References -- 2: The Liver as a Lymphoid Organ -- Introduction -- Liver Anatomy and Cell Composition -- Predominance of Innate Immunity in Liver -- Antigen-Presenting Cells -- Hepatocytes -- LSECs -- BECs -- KCs and Bone Marrow-Derived Macrophages -- DCs -- HSCs -- Innate Lymphocytes -- NKT Cells -- MAIT Cells -- NK Cells/Liver-Resident NK Cells -- Innate Lymphoid Cells (ILCs) -- γδ T Cells -- Adaptive Immune Cells -- T/B Cells -- Tissue-Resident Memory T (Trm) Cells -- Liver as a Tolerogenic Organ: Mechanisms -- Regulation of the Immune Response by the Liver Microenvironment -- Extracellular Matrix (ECM) Regulation of Immune Cell Response in the Liver -- Bile Acid Regulation of Immune Response in the Liver -- Metabolic Regulation of Liver Immune Response -- Hematopoiesis in the Liver -- Summary -- References -- 3: The Uniqueness of Innate Immunity -- Introduction -- Overview of Innate Immune Cell Types in the Liver -- Monocytes and Macrophages -- Kupffer Cells -- Granulocytes: Neutrophils, Basophils, and Eosinophils.
Umfang:
1 Online-Ressource (xv, 633 Seiten) Illustrationen
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ISBN:
9783030517090
Schlagworte:
Electronic books
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