Paediatric Formulation: Design and Development

The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration;...

Ausführliche Beschreibung

Gespeichert in:
Weitere Titel:
Paediatric Formulation
Hauptverfasser:
Lopalco, Antonio (HerausgeberIn), Denora, Nunzio (HerausgeberIn)
Format:
Elektronisch E-Book
Sprache:
Englisch
Veröffentlicht:
Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
Zusammenfassung:
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Umfang:
1 online resource (205 p.)
Anmerkungen:
English
Schlagworte:
Medicine
Bezugswerke: