Fast Facts : Comprehensive Genomic Profiling : Making precision medicine possible /

Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' p...

Ausführliche Beschreibung

Gespeichert in:
Weitere Titel:
Comprehensive Genomic Profiling
1. Verfasser:
Rapoport, Bernardo L.
Weitere Verfasser:
Troncone, Giancarlo, Schmitt, Fernando, Nayler, Simon J.
Format:
Elektronisch E-Book
Sprache:
Englisch
Veröffentlicht:
Basel : S. Karger, 2020
Ausgabe:
1st ed.
Zusammenfassung:
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy
Umfang:
1 online resource (108 pages) : 17 figures, 17 in color, 13 tables
Anmerkungen:
Text in English
ISBN:
9783318068191
3318068195
Schlagworte:
Oncology.
Biochemical markers.
Neoplasms > genetics.
DNA Fingerprinting > methods.
Bezugswerke:
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